|
KMID : 0356420060240010029
|
|
Journal of Korean Andrology
2006 Volume.24 No. 1 p.29 ~ p.34
|
|
|
Effect of Korean Red Ginseng on the Relaxation of Clitoral Corpus Cavernosum in Rabbit
|
|
Kim Sun-Ouck
Kim Min-Kyung
Chae Myeong-Jeong
Kim Hwi-Young
Park Jong-Kwan
Park Kwang-Sung
|
|
|
Abstract
|
|
|
Purpose: The purposes of this study were to investigate the effect of Korean Red Ginseng(KRG) extract on the relaxation of the clitoral corpus cavernosal smooth muscle in rabbit.
Materials and Methods: Rabbit clitoral corpus cavernosal smooth muscle strips were mounted in organ chambers to measure isometric tension. The strips were contracted with phenylephrine(5⁓106 M), and the responses to KRG extract(1∼20 mg/ml), nitric oxide inhibitor(Nՙ-nitro-L-arginine methyl ester, L-NAME), vasoactive intestinal peptide(VIP) receptor antagonist, KCl were examined. The cGMP content of the strips was measured by radioimmunoassay after various dose of KRG extract.
Results: The KRG extract(1∼20 mg/ml) relaxed the clitoral corpus cavernosal smooth muscle in a dose-dependent manner up to 95%. The relaxation effect of KRG extract was significantly inhibited by L-NAME(104 M) in clitoral corpus cavernosal smooth muscle. The KRG extract also inhibited the contraction induced by depolarization with 10, 20, 40 mM of KCl. The KRG extract(1, 5 mg/ml) increased the accumulation of cGMP in clitoral corpus cavernosal smooth muscle.
Conclusions: These data suggest that KRG extract has a relaxing effect on the clitoral corpus cavernosal smooth muscle in rabbit. These effects are in part mediated by the NO-cGMP pathway and a hyperpolarizing action.
|
|
|
KEYWORD
|
|
|
Korean red ginseng, Rabbits, Clitoris
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|